People
PRINCIPAL INVESTIGATORS

Jeffrey Bruce, M.D.
Co-Director, Brain Tumor Center Edgar M. Housepian Professor of Neurosurgery As Co-Director of the Brain Tumor Center, Dr. Bruce leads an NIH-funded translational brain tumor research effort with interests in immunotherapy and drug delivery systems. In addition to his laboratory research interests, he is actively involved in experimental clinical protocols for the treatment of brain tumors.

Peter Canoll, M.D.,Ph.D.
Co-Director, Brain Tumor Center Associate Professor of Pathology and Cell Biology Dr. Canoll is a neuropathologist who is Co-Director of the Brain Tumor Center. He has received several NIH-funded RO1 grants to study the regulation of glioma cell migration and proliferation and to further investigate interactions between glioma cells and adult progenitor cells in the PDGF model.

 

CURRENT LAB MEMBERS

Orlando D. Gil, Ph.D.
Lab Manager, Bruce Lab odg2103(at)columbia.edu Ph.D. Cell Biology, New York University
The role of tumor associated macrophages and microglia (TAMs) in modulating glioma initiation and progression. Using time-lapse microscopy to monitor TAMs’ cell movement within gliomas and in the peritumor area.

Liang Lei, Ph.D.
Associate Research Scientist, Canoll Lab
ll2239(at)columbia.edu
Ph.D., Cell and Developmental Biology, Rutgers (2004)
B.S. Cell and Developmental Biology, Wuhan University (1995)
Role of oligodendrocyte progenitor cells (OPC) in gliomagenesis, induction of OPC differentiation, and high-throughput RNA expression profiling in human and murine glioma.

Thanassis Dovas,

Ph.D.

Associate Research Scientist, Canoll Lab
ad3106(at)columbia.edu
Ph.D. Biochemistry, Imperial College, London (2006)
Tumor microenvironment, cell invasion and motility

Angelina Mela, Ph.D.
Associate Research Scientist, Canoll Lab
am2904(at)columbia.edu
Ph.D. Molecular Genetics, University of Patras, Greece (2006)
B.S. Biology, University of Patras, Greece (2001)
Glioma stem cell microenvironment, the perivascular and hypoxic niche and molecular mechanisms regulating the cross-talk between microenvironment and glioma stem-like cells

Jennifer S. Sims, Ph.D.
Postdoctoral Fellow, Bruce Lab jss2234(at)columbia.edu Ph.D. Microbiology & Molecular Genetics, Harvard University (2009)
B.S. Molecular Biology, UC San Diego (2004)
B.A. Literature/Writing, UC San Diego (2004)
T cell diversity in human and murine glioma progression, vaccine and immunotherapy

Matei A. Banu, M.D.
Postdoctoral Researcher, Bruce Lab
mab2315(at)columbia.edu
M.D. Carol Davila University of Medicine and Pharmacy, Bucharest, Romania (2011)
Glioma stem cell microenvironment, the perivascular and hypoxic niche and molecular mechanisms regulating the cross-talk between microenvironment and glioma stem-like cells

George Zanazzi, M.D.,Ph.D.
Clinical Fellow, Pathology
gz2209(at)cumc.columbia.edu
Ph.D. Neuroscience, Stony Brook University (2013)
B.S. Biological Sciences, Stanford University (1993)
Role of mTOR signaling in tumor-associated seizures

Brian J.A. Gill, M.D
Resident, Neurological Surgery (2014-present)
Doris Duke Fellow (2012-2013)
bjg2140(at)columbia.edu
M.D. College of Physicians and Surgeons, Columbia University (2014)
B.S. Case Western Reserve University (2009)
Investigation of Intratumoral Heterogeneity in GBMs with Sequential Stereotactically Localized Biopsies

Franklin Garcia
Ph.D student, Pathology & Cell Biology
fg2260(at)columbia.edu
B.S. Biology, University of California, Irvine (2010)

Daniela Torres
Ph.D. student, Pathology & Cell Biology
dt2410(at)columbia.edu
B.S., Biology, George Mason University (2010)
The role of mTOR signaling in glioma and its effects on translational regulation

Jorge L. Samanamud
Tumor Bank Technician
jls2216(at)columbia.edu
Biology, Minor in Chemistry, Hunter College (City University of New York)
Procurement of stereotactically localized biopsies for molecular applications
Methods of intraoperative neuronavigation for precision microsurgery
Clinical studies of time-resolved intraoperative therapeutic in brain tumors

Nancy Zhou
Senior Pathology Technician
hz65(at)columbia.edu
AFFILIATED CLINICAL & RESEARCH RESIDENCY FELLOWS
Big Ben
Benjamin Kennedy, M.D.
Chief Resident, Neurosurgery (2015-)
Resident, Neurosurgery (2009-2015)
Doris Duke Fellow (2007-2008)
bck2104(at)columbia.edu
M.D. College of Physicians and Surgeons, Columbia University (2009)
B.A., Cognitive Science and Biology, Northwestern University (2003) Dynamics of central and peripheral immunomodulation in a murine glioma model.

Jason A. Ellis,M.D.
Chief Resident, Neurosurgery (2015-)
Resident, Neurosurgery (2009-2015)
Doris Duke Fellow (2007-2008)
jae2109(at)columbia.edu
M.D., College of Physicians and Surgeons, Columbia University (2009)
M.A., Chemistry, Harvard University (2004)
B.A., Chemistry and Physics, Harvard University (2004)Endovascular treatment strategies for acute ischemic stroke.
I'm a medical professional
Hani R. Malone, M.D.
Resident, Neurosurgery (2010-)
hrm2104(at)columbia.edu
M.D., Columbia College of Physicians & Surgeons (2010)
B.A., Economics, Harvard University (2005)

Genetic and molecular heterogeneity in glioma. Glioma radiogenomics. Spine surgery clinical outcomes

Jonathan P. Yun, M.D.
Resident, Neurosurgery (2011-)
Doris Duke Fellow (2008-2009)
jpy2108(at)columbia.edu
M.D. College of Physicians and Surgeons, Columbia University (2011)
A novel adenoviral vector labeled with superparamagnetic iron oxide nanoparticles for real-time tracking of viral delivery.

Randy D’Amico, M.D.
Resident, Neurosurgery (2012-)
Doris Duke Fellow (2010-2011
rd2398(at)columbia.edu
M.D., UMDNJ – Robert Wood Johnson Medical School (2012)
B.A. Neuroscience, New York University
The addition of Sunitinib to radiation delays tumor growth in a murine model of glioblastoma.

Hannah E. Goldstein, M.D.
Resident, Neurosurgery (2013-)
Doris Duke Fellow (2011-2012)
M.D., Columbia College of Physicians & Surgeons (2013)

Nikita Alexiades, M.D.
Resident, Neurosurgery (2013-) M.D., University of Chicago Pritzker School of Medicine (2013)
B.S. Behavioral Neuroscience, Lehigh University (2009)
B.A., History, Lehigh University (2009)

Justin A. Neira, M.D.
PGY1, Neurosurgery (2015-)
Dept. of Neurological Surgery Student Research Fellowship (2013-2014)
jan2145(at)columbia.edu
M.D., College of Physicians & Surgeons (2015)
B.A., Biological Sciences, Cornell University (2010)

Convection-enhanced delivery in large animal models; utility of intraoperative indicators for neuronavigation

AFFILIATED CLINICAL FELLOWS & FACULTY

TUMOR LAB EXTENDED FAMILY
Enrico Suave
Richard C.E. Anderson, M.D.
Assistant Professor, Neurosurgery
rca24(at)columbia.edu
M.D., Johns Hopkins University School of Medicine (1997)
While practicing a broad range of pediatric neurosurgery, Dr. Anderson’s research interests in the immunology of pediatric brain tumors and biomechanics of the pediatric spine mirror his extensive clinical training in pediatric brain tumors and spinal disorders.

Adam W. Sonabend, M.D.
Dept. of Neurological Surgery
as3537(at)columbia.edu
M.D., National Autonomous University of Mexico Faculty of Medicine (2007)
Tumorigenic patterns of genomic alteration and gene expression in pro neural glioblastoma. Development and delivery of precision therapy based on molecular profiling of brain tumors.

LAB ALUMNI

Andrew T. Parsa, M.D.,Ph.D.
Chief Resident, Neurosurgery (2001-2002)
Resident, Neurosurgery (1996-2001)
Northwestern University
Chair, Department of Neurological Surgery
Michael J. Marchese Chair in Neurosurgery
Previously, University of California, San Francisco
Professor in Residence and Vice Chairman of Neurological Surgery
Principal Investigator, Brain Tumor Research Center Reza & Georgianna Khatib Chair in Skull Base Tumor Surgery

Passed away April 2015, see obituary
wazzup?
Allen E. Waziri, M.D.
Chief Resident, Neurosurgery (2007-08)
Resident, Neurosurgery (2001-07)
Inova Neuroscience Institute
Co-Director, Neuro-Oncology Program
Neurosurgeon, Inova Fairfax Hospital
Previously, University of Colorado, Denver
Assistant Professor, Colorado Health Sciences Center
Director, Brain Tumor Immunology laboratory
Co-director, Brain Monitoring laboratory

David Pisapia, M.D.
Postdoctoral Clinical Fellow, Pathology
djp26(at)columbia.edu
M.D. Cornell University (2009) Weill Cornell Medical College
Residency: New York-Presbyterian Hospital/Weill Cornell Medical Center
Fellowship: New York-Presbyterian Hospital/Columbia University Medical Center
Furthering the molecular characterization of brain tumors in an effort to reveal therapeutically and prognostically meaningful subclassifications of heterogeneous brain tumors that are often lumped into a single diagnostic entity. Chromatin topology of gliomas.

David Gass, M.D., M.Ed.
Postdoctoral Clinical Fellow, Pediatric Oncology (2012-2014) M.D., University of Buffalo (2007)
B.S., Film and Media Studies, University of Rochester (2000)

Marcela Assannah, Ph.D.
Postdoctoral Fellow, Canoll Lab Postdoctoral Fellow, Lead Research Scientist, Inova Health System
That's Rich
Richard Leung, M.D.
Postdoctoral Fellow, Canoll Lab
rl2533(at)columbia.edu
M.D. Medical School for International Health, Ben Gurion University, Israel (2011)
Various cellular populations in glioblastoma and their individual contributions to tumor progression. The role of CNS antigen sensitization in the suppression of CNS malignancy.

Kim Lopez, M.D.
Postdoctoral Fellow, Bruce Lab (2005-2009) Senior Consultant, Health and Life Sciences, Oliver Wyman

FORMER STUDENTS & TECHNICIANS
Christine J. Wang Undergraduate Research Assistant
christine_wang@hms.harvard.edu
Medical Student, Harvard University (2015-)B.A., Hispanic Studies, Columbia University (2015)
Molecular characterization of immunology and cell biology during tumorigenesis in a murine model of proneural glioma.
Caroline E. Aronin Research Assistant (2013-2014)
caronin1(at)jhu.edu
Undergraduate student, Johns Hopkins University (2015-)
Mamaroneck High School (Graduated class of 2015)
Identification of T cell receptors responsive to cytokine perturbation in a murine model of pro neural glioma.

Timothy H. Ung
Dept. of Neurological Surgery Student Research Fellowship (2014-15)
timothy.ung(at)ucdenver.edu
University of Colorado, Denver (M.D. expected 2016)
Refining neuronavigation for improved outcomes with resection of tumorigenic tissue at the margins of GBM
Small Ben
Benjamin I. Amendolara
Research Technician
ba2349(at)columbia.edu
M.D./Ph.D. student at University of California-Los Angeles (2014-)
B.A. English Literature, Haverford College (2010)
Evaluating the use of fasudil, a clinically available rho kinase inhibitor, to block glioma dispersion in vitro and in vivo. Intratumoral convection-enhanced delivery (CED) of anti-CD25 to abolish regulatory T cells at the tumor site, in order to promote an effective immune response.

Matthew Nazarian
Tumor Bank Technician
matthew.nazarian(at)jefferson.edu
Medical student at Sidney Kimmel Medical College, Thomas Jefferson University (2013-)
B.S. Biology, Tufts University (2012)
The role of surgical resection in treating patients with glioblastomas.

Robert J. Rothrock, M.D.
Doris Duke Fellow (2012-13)
rr2279(at)columbia.edu
Resident, Neurosurgery, Mount Sinai Hospital (2014-)
M.D. Albert Einstein College of Medicine (2014)
B.A. European History, University of Pennsylvania (2008)
Phase Ib Trial of Etoposide by Convection Enhanced Delivery (CED) for the Treatment of Recurrent High Grade Glioma. Database of Clinical Management of Low Grade Gliomas. The effect of Statins and COX-inhibitors on survival in GBM.

Simon Sung, M.D.
Medical Student Research Assistant (2013)
ss3768(at)columbia.edu
Resident, Dept. of Pathology, Columbia University (2013-)
M.D. College of Physicians and Surgeons, Columbia University (2013)

Zahra Bhaiwala
Undergraduate Research Assistant Masters program in Global Health, Harvard School of Public Health
B.A. Biology and Middle Eastern, South Asian, and African Studies, Columbia University (2014)
Determinants of anti-tumor T cell responses in low and high-grade glioma.

Jordan Lebovic
Undergraduate Research Assistant jal2231(at)columbia.edu B.A. Biochemistry and Statistics, Columbia University (2014)
Tumor heterogeneity and the activities of various genetic components of glioblastoma.

Jane O, M.D.
Doris Duke Fellow (2012-2013)
jmo2103(at)columbia.edu
M.D. Columbia University (2014)
B.A. Molecular and Cell Biology, Univ. of California, Berkeley (2009)
Validating genes involved in gliomagenesis. Evaluating outcomes in patients undergoing surgery for pineal region tumors.
Baby Showers
Christopher R. Showers
Doris Duke Fellow (2012-2013)
crs2160(at)columbia.edu
Per1 single nucleotide mutation prevalence in GBM and LGG. Extent of Resection surgeon survey to address consensus on area of eloquence and resectabilty of GBM. Retrospective case series of craniopharyngioma highlight outcome measure with different surgical approaches. Macrophages/Microglia and their influence on glioma progression.

Michael B. Cloney, M.D.
Medical Student Research Assistant
mbc2121(at)columbia.edu
M.D. Columbia University (2015)
B.A. Biophysics, Columbia University (2010)
Impact and determinants of the extent of surgical resection in glioblastomas.

Sonal Noticewala
Undergraduate Research Assistant (2010-12)
snoticewala(at)ucsd.edu
Univ. of California, San Diego (M.D. class of 2016)
B.S. Biochemistry, Columbia University (2012)

Using time-lapse microscopy to study the migratory behavior of glioma cells in mice.
Arnold
Vadim (Eddie) Tsvankin, M.D.
Hamilton Research Fellow (2011-12) Resident, Neurosurgery, Duke University (2013-)
M.D. Univ. of Colorado, Denver (2013)
B.S., Cell and Developmental Biology, Univ. of Colorado, Boulder (2008)
Intratumoral convection-enhanced delivery (CED) of anti-CD25 to abolish regulatory T cells at the tumor site, in order to promote an effective immune response.

Victoria Ebiana, M.D.
Doris Duke Fellow, (2011-2012) Resident, Neurology, Univ. of California, Los Angeles (2014-)
M.D., College of Physicians & Surgeons, Columbia University (2013)
B.S. Harvard University (2008)
Immunohistology of glioma, role of surgical preference in resection of glioblastoma
This guy's name is Artie
Arthur Carminucci, M.D.
Doris Duke Fellow, (2011-2012) Resident at Neurological Institute of New Jersey
M.D., UMDNJ – Robert Wood Johnson Medical School (2013)
Convection-enhanced delivery (CED) of topoisomerase II inhibitors in murine glioma.

Jina Lim
Undergraduate, Columbia University yjl2105(at)columbia.edu B.A. Biology, Columbia University (Expected 2013) Using time-lapse microscopy to study the migratory behavior of glioma cells in mice.

Leif-Erik Bohman, M.D.
Doris Duke Fellow (2006-07) M.D. College of Physicians and Surgeons, Columbia University (2008)
Magnetic resonance imaging characteristics of glioblastoma multiforme: implications for understanding glioma ontogeny.

Monique Vanaman
Doris Duke Fellow (2006-07) M.D. College of Physicians and Surgeons, Columbia University (2008)
The Value of Prenatal MRI for Prenatal Neurosurgical Counseling
Celina Crisman Doris Duke Fellow (2009-10) M.D. College of Physicians and Surgeons, Columbia University (2011)The addition of Sunitinib to radiation delays tumor growth in a murine model of glioblastoma.

Craig Soderquist
Doris Duke Fellow (2009-10) M.D. College of Physicians & Surgeons, Columbia University (2011)
Glioblastoma models reveal the connection between adult glial progenitors and the proneural phenotype.

Isaac Chan
Doris Duke Fellow, 2008-2009 Resident at Yale School of Medicine Department of Emergency Medicine
M.D. College of Physicians and Surgeons, Columbia University (2010)

Marie Roguski
Doris Duke Fellow, 2008-2009 M.D., College of Physicians and Surgeons, Columbia University

Katy Linsky
Doris Duke Fellow (2007-08) M.D. University of Hawaii (2009)The Role of Brain Biopsy in Diagnosis of Central Nervous System Vasculitis

David J.Fusco, M.D.
Doris Duke Fellow (2005-06) M.D. Columbia University (2007)
Expansion of Neural Progenitor Cells in Non-Astrocytic, Non-Oligodendroglial CNS Neoplasms


Kai Canoll
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